DADEPYLIPQQG
- Product Name
- DADEPYLIPQQG
- Chemical Name
- DADEPYLIPQQG
- Synonyms
- EGFR;DADEPYLIPQQG;EGFR (988-998);DADEY(PO3)LIPQQG;Mouse Anti-EGFR antibody;Rat EGFR Protein, His Tag;Mouse EGFR Protein, Fc Tag;Human EGFR Protein, Fc Tag;Mouse EGFR Protein, His Tag;Human EGFR Protein, His Tag
- CBNumber
- CB2770154
- Molecular Formula
- C54H82N13O24P
- Formula Weight
- 1328.28
- MOL File
- Mol file
DADEPYLIPQQG Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- E3641
- Product name
- Epidermal Growth Factor Receptor human
- Purity
- buffered aqueous glycerol solution, 5,000-30,000?units/mg protein (Lowry)
- Packaging
- 500units
- Price
- $759
- Updated
- 2024/03/01
- Product number
- E2645
- Product name
- Epidermal Growth Factor Receptor human
- Purity
- lyophilized powder, ≥15,000?units/mg protein (Bradford)
- Packaging
- 500UNITS
- Price
- $586
- Updated
- 2023/06/20
- Product number
- 369876
- Product name
- EGFR
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 382729
- Product name
- EGFR
- Packaging
- 96Tests
- Price
- $669
- Updated
- 2021/12/16
- Product number
- 472035
- Product name
- EGFR
- Packaging
- 96Tests
- Price
- $731
- Updated
- 2021/12/16
DADEPYLIPQQG Chemical Properties,Usage,Production
General Description
Epidermal growth factor receptor (EGFR) belongs to a family of cell surface receptors called receptor tyrosine kinases (RTKs), and is also the most studied member of this family. It is made up of an ectodomain (ECD), which contains four subdomains called DI-DIV, a transmembrane region, and a cytoplasmic tyrosine kinase domain (TKD). Binding of the ligand induces conformational changes in the ECD, which leads to the dimerization of EGFR. This results in the activation of the TKD, and the subsequent signal transduction. This receptor has a molecular weight of ～178kDa.
Biochem/physiol Actions
EGF exerts its actions by binding to the EGF receptor (EGFR), a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Even in the absence of EGF-like ligands, EGFR can participate in cellular responses elicited by several other stimuli. High levels of EGFR are expressed in approximately one third of human epithelial tumors, and in the cancers of the bladder, breast or lung that have poor clinical prognosis, hence the interest in targeting EGFR.